PUBBLICAZIONI

Bezzerri, V., Gentili, V., Api, M., Finotti, A., Papi, C., Tamanini, A., Boni, C., Baldisseri, E., Olioso, D., Duca, M., Tedesco, E., Leo, S., Borgatti, M., Volpi, S., Pinton, P., Cabrini, G., Gambari, R., Blasi, F., Lippi, G., Rimessi, A., Rizzo, R., Cipolli, M. (2023) SARS-CoV-2 viral entry and replication is impaired in Cystic Fibrosis airways due to ACE2 downregulation. Nat Commun. 14,132

Rossi, A., Bragonzi, A., Medede, M., De Fino, I., Lippi, G., Prosdocimi, M., Tamanini, A.,Cabrini, G., Dechecchi, M.C. (2023) β-sitosterol ameliorates inflammation and Pseudomonas aeruginosa lung infection in a mouse model. J Cyst Fibros. 22,156-160

Ribeiro, C.M.P., Higgs, M.G., Muhlebach, M.S., Wolfgang, M.C., Borgatti, M., Lampronti, I., Cabrini, G. (2023) Revisiting Host-Pathogen Interactions in Cystic Fibrosis Lungs in the Era of CFTR Modulators. Int J Mol Sci. 24,5010 [Review]

Cabrini, G. (2022) CFTR Modulators and Reduction of Airway Inflammation in Cystic Fibrosis: How Much is Enough? Curr Med Chem. Oct 14. [Editorial]

Tupini, C., Chilin, A., Rossi, A., De Fino, I., Bragonzi, A., D’Aversa, E., Cosenza, L.C.,Vaccarin, C., Sacchetti, G., Borgatti, M., Tamanini, A., Dechecchi, M.C., Sanvito, F.,Gambari, R., Cabrini, G., Lampronti, I. (2022) New TMA (4,6,4′-Trimethyl angelicin)Analogues as Anti-Inflammatory Agents in the Treatment of Cystic Fibrosis Lung Disease. Int J Mol Sci. 23, 14483

Vaccarin, C., Gabbia, D., Franceschinis, E., De Martin, S., Roverso, M., Bogialli, S.,Sacchetti, G., Tupini, C., Lampronti, I., Gambari, R., Cabrini, G., Dechecchi, M.C., Tamanini, A., Marzaro, G., Chilin, A. (2022) Improved Trimethylangelicin Analogs for Cystic Fibrosis: Design, Synthesis and Preliminary Screening. Int J Mol Sci. 23, 11528

Franceschinis, E., Roverso, M., Gabbia, D., De Martin, S., Brusegan, M., Vaccarin, C., Bogialli, S., Chilin, A. (2022) Self-Emulsifying Formulations to Increase the Oral Bioavailability of 4,6,4′-Trimethylangelicin as a Possible Treatment for Cystic Fibrosis. Pharmaceutics 14, 1806

Cabrini, G., Rimessi, A., Borgatti, M., Pinton, P., Gambari, R. (2022) Overview of CF lung pathophysiology. Curr Opin Pharmacol. 64,102214 [Review]

Ribeiro, C.M.P., McElvaney, N.G., Cabrini, G. (2021) Novel Anti-Inflammatory Approaches for Cystic Fibrosis Lung Disease: Identification of Molecular Targets and Design of Innovative Therapies. Front Pharmacol. 12,794854 [Editorial]

Rimessi, A., Vitto, V.A.M., Patergnani, S., Pinton, P. (2021) Update on Calcium Signaling in Cystic Fibrosis Lung Disease. Front Pharmacol. 12,581645 [Review]

Patergnani, S., Bouhamida, E., Leo, S., Pinton, P., Rimessi, A. (2021) Mitochondrial Oxidative Stress and “Mito-Inflammation”: Actors in the Diseases. Biomedicines. 9,216 [Review]

Rimessi, A., Pozzato, C., Carparelli, L., Rossi, A., Ranucci, S., De Fino, I., Cigana, C., Talarico, A., Wieckowski, M. R., Ribeiro, C. M. P., Trapella, C., Rossi, G., Cabrini, G., Bragonzi, A., and Pinton, P. (2020) Pharmacological modulation of mitochondrial calcium uniporter controls lung inflammation in cystic fibrosis.  Sci Adv 6, eaax9093

Quercini L, Brunetti J, Riolo G, Bindi S, Scali S, Lampronti I, D’Aversa E, Wronski S, Pollini S, Gentile M, Lupetti P, Rossolini GM, Falciani C, Bracci L, Pini A. (2020) An antimicrobial molecule mitigates signs of sepsis in vivo and eradicates infections from lung tissue. FASEB J, 34,192-207.

Cabrini, G., Rimessi, A., Borgatti, M., Lampronti, I., Finotti, A., Pinton, P., and Gambari, R. (2020)  Role of Cystic Fibrosis Bronchial Epithelium in Neutrophil Chemotaxis. Front Immunol 11, 1438 [Review]

Patergnani, S., Vitto, V. A. M., Pinton, P., and Rimessi, A. (2020)  Mitochondrial Stress Responses and “Mito-Inflammation” in Cystic Fibrosis. Front Pharmacol 11, 581114 [Review]

Gasparello, J., Lomazzi, M., Papi, C., D’Aversa, E., Sansone, F., Casnati, A., Donofrio, G., Gambari, R., and Finotti, A. (2019) Efficient Delivery of MicroRNA and AntimiRNA Molecules Using an Argininocalix[4]arene Macrocycle. Mol Ther Nucleic Acids 18, 748-763

De Fenza, M., D’Alonzo, D., Esposito, A., Munari, S., Loberto, N., Santangelo, A., Lampronti, I., Tamanini, A., Rossi, A., Ranucci, S., De Fino, I., Bragonzi, A., Aureli, M., Bassi, R., Tironi, M., Lippi, G., Gambari, R., Cabrini, G., Palumbo, G., Dechecchi, M. C., and Guaragna, A. (2019) Exploring the effect of chirality on the therapeutic potential of N-alkyl-deoxyiminosugars: anti-inflammatory response to Pseudomonas aeruginosa infections for application in CF lung disease. Eur J Med Chem 175, 63-71

Rimessi, A., Bezzerri, V., Salvatori, F., Tamanini, A., Nigro, F., Dechecchi, M. C., Santangelo, A., Prandini, P., Munari, S., Provezza, L., Garreau de Loubresse, N., Muller, J., Ribeiro, C. M. P., Lippi, G., Gambari, R., Pinton, P., and Cabrini, G. (2018) PLCB3 Loss of Function Reduces Pseudomonas aeruginosa-Dependent IL-8 Release in Cystic Fibrosis. Am J Respir Cell Mol Biol 59, 428-436

Marzaro, G., Lampronti, I., D’Aversa, E., Sacchetti, G., Miolo, G., Vaccarin, C., Cabrini, G., Dechecchi, M. C., Gambari, R., and Chilin, A. (2018) Design, synthesis and biological evaluation of novel trimethylangelicin analogues targeting nuclear factor kB (NF-kB). Eur J Med Chem 151, 285-293

Schiumarini, D., Loberto, N., Mancini, G., Bassi, R., Giussani, P., Chiricozzi, E., Samarani, M., Munari, S., Tamanini, A., Cabrini, G., Lippi, G., Dechecchi, M. C., Sonnino, S., and Aureli, M. (2017) Evidence for the Involvement of Lipid Rafts and Plasma Membrane Sphingolipid Hydrolases in Pseudomonas aeruginosa Infection of Cystic Fibrosis Bronchial Epithelial Cells. Mediators Inflamm 2017, 1730245

Montagner, G., Bezzerri, V., Cabrini, G., Fabbri, E., Borgatti, M., Lampronti, I., Finotti, A., Nielsen, P. E., and Gambari, R. (2017) An antisense peptide nucleic acid against Pseudomonas aeruginosa inhibiting bacterial-induced inflammatory responses in the cystic fibrosis IB3-1 cellular model system. Int J Biol Macromol 99, 492-498

Lampronti, I., Manzione, M. G., Sacchetti, G., Ferrari, D., Spisani, S., Bezzerri, V., Finotti, A., Borgatti, M., Dechecchi, M. C., Miolo, G., Marzaro, G., Cabrini, G., Gambari, R., and Chilin, A. (2017) Differential Effects of Angelicin Analogues on NF-kappaB Activity and IL-8 Gene Expression in Cystic Fibrosis IB3-1 Cells. Mediators Inflamm 2017, 2389487

Lampronti, I., Dechecchi, M. C., Rimessi, A., Bezzerri, V., Nicolis, E., Guerrini, A., Tacchini, M., Tamanini, A., Munari, S., D’Aversa, E., Santangelo, A., Lippi, G., Sacchetti, G., Pinton, P., Gambari, R., Agostini, M., and Cabrini, G. (2017) Beta-Sitosterol Reduces the Expression of Chemotactic Cytokine Genes in Cystic Fibrosis Bronchial Epithelial Cells. Front Pharmacol 8, 236

Prandini, P., De Logu, F., Fusi, C., Provezza, L., Nassini, R., Montagner, G., Materazzi, S., Munari, S., Gilioli, E., Bezzerri, V., Finotti, A., Lampronti, I., Tamanini, A., Dechecchi, M. C., Lippi, G., Ribeiro, C. M., Rimessi, A., Pinton, P., Gambari, R., Geppetti, P., and Cabrini, G. (2016) Transient Receptor Potential Ankyrin 1 Channels Modulate Inflammatory Response in Respiratory Cells from Patients with Cystic Fibrosis. Am J Respir Cell Mol Biol 55, 645-656

Rimessi, A., Previati, M., Nigro, F., Wieckowski, M. R., and Pinton, P. (2016) Mitochondrial reactive oxygen species and inflammation: Molecular mechanisms, diseases and promising therapies. Int J Biochem Cell Biol 81, 281-293 [Review]

Cigana, C., Lore, N. I., Riva, C., De Fino, I., Spagnuolo, L., Sipione, B., Rossi, G., Nonis, A., Cabrini, G., and Bragonzi, A. (2016) Tracking the immunopathological response to Pseudomonas aeruginosa during respiratory infections. Sci Rep 6, 21465

Brunetti, J., Roscia, G., Lampronti, I., Gambari, R., Quercini, L., Falciani, C., Bracci, L., and Pini, A. (2016) Immunomodulatory and Anti-inflammatory Activity in Vitro and in Vivo of a Novel Antimicrobial Candidate. J Biol Chem 291, 25742-25748

Rimessi, A., Bezzerri, V., Patergnani, S., Marchi, S., Cabrini, G., and Pinton, P. (2015) Mitochondrial Ca2+-dependent NLRP3 activation exacerbates the Pseudomonas aeruginosa-driven inflammatory response in cystic fibrosis. Nat Commun 6, 6201

Milani, R., Marcellini, A., Montagner, G., Baldisserotto, A., Manfredini, S., Gambari, R., and Lampronti, I. (2015) Phloridzin derivatives inhibiting pro-inflammatory cytokine expression in human cystic fibrosis IB3-1 cells. Eur J Pharm Sci 78, 225-233

Loberto, N., Tebon, M., Lampronti, I., Marchetti, N., Aureli, M., Bassi, R., Giri, M. G., Bezzerri, V., Lovato, V., Cantu, C., Munari, S., Cheng, S. H., Cavazzini, A., Gambari, R., Sonnino, S., Cabrini, G., and Dechecchi, M. C. (2014) GBA2-encoded beta-glucosidase activity is involved in the inflammatory response to Pseudomonas aeruginosa. PLoS One 9, e104763

Guerrini, A., Mancini, I., Maietti, S., Rossi, D., Poli, F., Sacchetti, G., Gambari, R., and Borgatti, M. (2014) Expression of pro-inflammatory interleukin-8 is reduced by ayurvedic decoctions. Phytother Res 28, 1173-1181

Fabbri, E., Borgatti, M., Montagner, G., Bianchi, N., Finotti, A., Lampronti, I., Bezzerri, V., Dechecchi, M. C., Cabrini, G., and Gambari, R. (2014) Expression of microRNA-93 and Interleukin-8 during Pseudomonas aeruginosa-mediated induction of proinflammatory responses. Am J Respir Cell Mol Biol 50, 1144-1155

Bezzerri, V., Avitabile, C., Dechecchi, M. C., Lampronti, I., Borgatti, M., Montagner, G., Cabrini, G., Gambari, R., and Romanelli, A. (2014) Antibacterial and anti-inflammatory activity of a temporin B peptide analogue on an in vitro model of cystic fibrosis. J Pept Sci 20, 822-830

Marzaro, G., Guiotto, A., Borgatti, M., Finotti, A., Gambari, R., Breveglieri, G., and Chilin, A. (2013) Psoralen derivatives as inhibitors of NF-kappaB/DNA interaction: synthesis, molecular modeling, 3D-QSAR, and biological evaluation. J Med Chem 56, 1830-1842

Lampronti, I., Borgatti, M., Vertuani, S., Manfredini, S., and Gambari, R. (2013) Modulation of the expression of the proinflammatory IL-8 gene in cystic fibrosis cells by extracts deriving from olive mill waste water. Evid Based Complement Alternat Med 2013, 960603

Gambari, R., Borgatti, M., Lampronti, I., Fabbri, E., Brognara, E., Bianchi, N., Piccagli, L., Yuen, M. C., Kan, C. W., Hau, D. K., Fong, W. F., Wong, W. Y., Wong, R. S., and Chui, C. H. (2012) Corilagin is a potent inhibitor of NF-kappaB activity and downregulates TNF-alpha induced expression of IL-8 gene in cystic fibrosis IB3-1 cells. Int Immunopharmacol 13, 308-315

Finotti, A., Borgatti, M., Bezzerri, V., Nicolis, E., Lampronti, I., Dechecchi, M., Mancini, I., Cabrini, G., Saviano, M., Avitabile, C., Romanelli, A., and Gambari, R. (2012) Effects of decoy molecules targeting NF-kappaB transcription factors in Cystic fibrosis IB3-1 cells: recruitment of NF-kappaB to the IL-8 gene promoter and transcription of the IL-8 gene. Artif DNA PNA XNA 3, 97-296

Tamanini, A., Borgatti, M., Finotti, A., Piccagli, L., Bezzerri, V., Favia, M., Guerra, L., Lampronti, I., Bianchi, N., Dall’Acqua, F., Vedaldi, D., Salvador, A., Fabbri, E., Mancini, I., Nicolis, E., Casavola, V., Cabrini, G., and Gambari, R. (2011) Trimethylangelicin reduces IL-8 transcription and potentiates CFTR function. Am J Physiol Lung Cell Mol Physiol 300, L380-390

Mazzitelli, S., Borgatti, M., Breveglieri, G., Gambari, R., and Nastruzzi, C. (2011) Encapsulation of eukaryotic cells in alginate microparticles: cell signaling by TNF-alpha through capsular structure of cystic fibrosis cells. J Cell Commun Signal 5, 157-165

Dechecchi, M. C., Nicolis, E., Mazzi, P., Cioffi, F., Bezzerri, V., Lampronti, I., Huang, S., Wiszniewski, L., Gambari, R., Scupoli, M. T., Berton, G., and Cabrini, G. (2011) Modulators of sphingolipid metabolism reduce lung inflammation. Am J Respir Cell Mol Biol 45, 825-833

Borgatti, M., Mancini, I., Bianchi, N., Guerrini, A., Lampronti, I., Rossi, D., Sacchetti, G., and Gambari, R. (2011) Bergamot (Citrus bergamia Risso) fruit extracts and identified components alter expression of interleukin 8 gene in cystic fibrosis bronchial epithelial cell lines.  BMC Biochem 12, 15

Borgatti, M., Chilin, A., Piccagli, L., Lampronti, I., Bianchi, N., Mancini, I., Marzaro, G., dall’Acqua, F., Guiotto, A., and Gambari, R. (2011) Development of a novel furocoumarin derivative inhibiting NF-kappaB dependent biological functions: design, synthesis and biological effects. Eur J Med Chem 46, 4870-4877

Bezzerri, V., d’Adamo, P., Rimessi, A., Lanzara, C., Crovella, S., Nicolis, E., Tamanini, A., Athanasakis, E., Tebon, M., Bisoffi, G., Drumm, M. L., Knowles, M. R., Pinton, P., Gasparini, P., Berton, G., and Cabrini, G. (2011) Phospholipase C-beta3 is a key modulator of IL-8 expression in cystic fibrosis bronchial epithelial cells. J Immunol 186, 4946-4958

Bezzerri, V., Borgatti, M., Finotti, A., Tamanini, A., Gambari, R., and Cabrini, G. (2011) Mapping the transcriptional machinery of the IL-8 gene in human bronchial epithelial cells. J Immunol 187, 6069-6081

Piccagli, L., Borgatti, M., Nicolis, E., Bianchi, N., Mancini, I., Lampronti, I., Vevaldi, D., Dall’Acqua, F., Cabrini, G., and Gambari, R. (2010) Virtual screening against nuclear factor kappaB (NF-kappaB) of a focus library: Identification of bioactive furocoumarin derivatives inhibiting NF-kappaB dependent biological functions involved in cystic fibrosis.  Bioorg Med Chem 18, 8341-8349

Cabrini, G., Bezzerri, V., Mancini, I., Nicolis, E., Dechecchi, M. C., Tamanini, A., Lampronti, I., Piccagli, L., Bianchi, N., Borgatti, M., and Gambari, R. (2010) Targeting transcription factor activity as a strategy to inhibit pro-inflammatory genes involved in cystic fibrosis: decoy oligonucleotides and low-molecular weight compounds. Curr Med Chem 17, 4392-4404 [Review]

Gambari, R., Borgatti, M., Bezzerri, V., Nicolis, E., Lampronti, I., Dechecchi, M. C., Mancini, I., Tamanini, A., and Cabrini, G. (2010) Decoy oligodeoxyribonucleotides and peptide nucleic acids-DNA chimeras targeting nuclear factor kappa-B: inhibition of IL-8 gene expression in cystic fibrosis cells infected with Pseudomonas aeruginosa. Biochem Pharmacol 80, 1887-1894

Borgatti, M., Mazzitelli, S., Breveglieri, G., Gambari, R., and Nastruzzi, C. (2010) Induction by TNF-alpha of IL-6 and IL-8 in cystic fibrosis bronchial IB3-1 epithelial cells encapsulated in alginate microbeads. J Biomed Biotechnol 2010

Piccagli, L., Fabbri, E., Borgatti, M., Bianchi, N., Bezzerri, V., Mancini, I., Nicolis, E., Dechecchi, C. M., Lampronti, I., Cabrini, G., and Gambari, R. (2009) Virtual screening against p50 NF-kappaB transcription factor for the identification of inhibitors of the NF-kappaB-DNA interaction and expression of NF-kappaB upregulated genes. ChemMedChem 4, 2024-2033

Nicolis, E., Lampronti, I., Dechecchi, M. C., Borgatti, M., Tamanini, A., Bezzerri, V., Bianchi, N., Mazzon, M., Mancini, I., Giri, M. G., Rizzotti, P., Gambari, R., and Cabrini, G. (2009) Modulation of expression of IL-8 gene in bronchial epithelial cells by 5-methoxypsoralen. Int Immunopharmacol 9, 1411-1422

Copreni, E., Nicolis, E., Tamanini, A., Bezzerri, V., Castellani, S., Palmieri, L., Giri, M. G., Vella, A., Colombatti, M., Rizzotti, P., Conese, M., and Cabrini, G. (2009) Late generation lentiviral vectors: evaluation of inflammatory potential in human airway epithelial cells. Virus Res 144, 8-17

Nicolis, E., Lampronti, I., Dechecchi, M. C., Borgatti, M., Tamanini, A., Bianchi, N., Bezzerri, V., Mancini, I., Giri, M. G., Rizzotti, P., Gambari, R., and Cabrini, G. (2008)  Pyrogallol, an active compound from the medicinal plant Emblica officinalis, regulates expression of pro-inflammatory genes in bronchial epithelial cells. Int Immunopharmacol 8, 1672-1680

Dechecchi, M. C., Nicolis, E., Norez, C., Bezzerri, V., Borgatti, M., Mancini, I., Rizzotti, P., Ribeiro, C. M., Gambari, R., Becq, F., and Cabrini, G. (2008) Anti-inflammatory effect of miglustat in bronchial epithelial cells. J Cyst Fibros 7, 555-565

Bezzerri, V., Borgatti, M., Nicolis, E., Lampronti, I., Dechecchi, M. C., Mancini, I., Rizzotti, P., Gambari, R., and Cabrini, G. (2008) Transcription factor oligodeoxynucleotides to NF-kappaB inhibit transcription of IL-8 in bronchial cells. Am J Respir Cell Mol Biol 39, 86-96

Dechecchi, M. C., Nicolis, E., Bezzerri, V., Vella, A., Colombatti, M., Assael, B. M., Mettey, Y., Borgatti, M., Mancini, I., Gambari, R., Becq, F., and Cabrini, G. (2007) MPB-07 reduces the inflammatory response to Pseudomonas aeruginosa in cystic fibrosis bronchial cells. Am J Respir Cell Mol Biol 36, 615-624

Borgatti, M., Bezzerri, V., Mancini, I., Nicolis, E., Dechecchi, M. C., Lampronti, I., Rizzotti, P., Cabrini, G., and Gambari, R. (2007) Induction of IL-6 gene expression in a CF bronchial epithelial cell line by Pseudomonas aeruginosa is dependent on transcription factors belonging to the Sp1 superfamily. Biochem Biophys Res Commun 357, 977-983